Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines
نویسندگان
چکیده
منابع مشابه
Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes.
The N-hydroxylation of carcinogenic arylamines represents an initial step in their metabolic activation. Animal studies have shown that this reaction is catalyzed by the cytochrome P450 (P450) enzymes P450 1A1 and P450 1A2. In this study, utilizing enzymes expressed in Escherichia coli (and purified) or in human B-lymphoblastoid cells, the catalytic activities of recombinant human P450 1A1, P45...
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The aromatic amines 2-aminofluorene (2AF), 2-acetylaminofluorene, and 2-aminoanthracene, and the heterocyclic amines 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, and 3-amino-1-methyl-SH-pyrido[4,3-b]indole (Trp-P-2) were activated by rat liver cytosolic fractions to form mutagenic metabolites in Salmonella typhimurium strains TA98, TA98NR, and TA98/...
متن کاملN-hydroxylation of carcinogenic and mutagenic aromatic amines.
N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole), Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole), Glu-P-1 (2-amino-6-methyldipyrido-[1,2-a...
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The consumption of fish provides utilization of proteins of high biological value, certain minerals, and vitamins. Additionally, fish and fish oil are rich sources of omega-3 fatty acids. Sardine (Sardina pilchardus) and salmon (Salmo salar) are fish species rich in omega-3 PUFAs. On the other hand, fish is usually cooked in different ways before consumption and heat treatment can lead to undes...
متن کاملTranscription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
Klotho (KL), originally discovered as an aging suppressor, is a membrane protein that shares sequence similarity with the β-glucosidase enzymes. Recent reports showed Klotho might play a role in adipocyte maturation and systemic glucose metabolism. However, little is known about the transcription factors involved in regulating the expression of porcine KL gene. Deletion fragment analysis identi...
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 2019
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2018.08.015